Live Well Vitamins & Lifestyle Guide

DHEA (Dehydroepiandrosterone)

DHEA (dehydroepiandrosterone) is a hormone that's naturally produced by the adrenal glands. Levels of DHEA naturally drop after age 30. Some people take DHEA supplements in the hopes that DHEA will have health benefits and prevent some illnesses. However, the evidence is mixed.

DHEA Uses

A number of studies have found that DHEA supplements may help people with depression, obesity, lupus, and adrenal insufficiency. DHEA may also improve skin in older people and help treat osteoporosis and erectile dysfunction.

Low DHEA levels are associated with aging and a number of diseases, such as anorexia, type 2 diabetes, and HIV. In older men, having low levels of DHEA is also associated with a higher chance of death. However, it's not clear that using DHEA supplements will help lower the risks of getting any diseases.

DHEA is used by some people who want to "reverse" aging and boost immunity, cognitive function, and muscle strength. For now, studies don't back up these uses. DHEA has been studied as a treatment for other conditions, ranging from cardiovascular disease to Alzheimer's. The results have been unclear.

DHEA Dose & Instructions for Use

There is no standard dosage of DHEA. Some studies have used between 25 and 200 milligrams a day. Ask your doctor for advice.

DHEA Food Sources

There are no food sources of DHEA. The body manufactures DHEA naturally in the adrenal glands.

DHEA Supplement Information

DHEA supplements come in tablets, capsules, injections, and creams. Like any supplement, keep DHEA in a cool, dry place, away from humidity and direct sunlight.

DHEA Warnings

• Side effects. Most side effects are mild, like headache, fatigue, and congestion. Because DHEA affects hormone levels, it can cause other symptoms. Women may have abnormal periods or mood changes. They might also take on masculine characteristics, such as facial hair or a deeper voice. Men might develop more breast tissue, high blood pressure, and other problems.
• Risks. Using high doses of DHEA may not be safe. People who have heart problems, liver disease, diabetes, high cholesterol, thyroid problems, polycystic ovary syndrome, and a history of clotting problems should not use DHEA. DHEA may increase the risk of some cancers that are affected by hormones, like cancers of the breast, ovaries, and prostate.
• Interactions. If you take any medicines regularly, talk to your doctor before you start using DHEA supplements. They could interact with blood thinners, anticonvulsants, hormone therapy, and medicines for diabetes and heart or liver problems.

Because DHEA is a powerful hormone, it is not recommended for children or for women who are pregnant or breastfeeding.